Effects of Toxicants on Gene Expression and Intracellular Signalling

STOCKHOLM, SWEDEN, SEPTEMBER 14-16, 1997

 Det senaste symposiet, som var det femte i ordningen hade titeln "Effects of Toxicants on Gene Expression and Intracellular Signalling". Det hölls på Vår Gård i Saltsjöbaden utanför Stockholm den 14-16 september 1997. Det vetenskapliga programmet behandlade hur farmakologiska och toxiska ämnen aktiverar intracellulära signalsystem, förändrar genuttryck och påverkar cell-cykeln. Möjligheten att använda kunskapen om dessa processer för toxikologiska bedömningar och riskvärdering behandlades också. Symposiets forskningsområde bedöms som viktigt för etableringen av djurfria metoder för studier av toxiska effekter.

Programmet bestod av sessionerna: "Signal transduction", "Cell cycle/death", "Stress response" och "Application of molecular biology in in vitro toxicology".

Proceedings från symposiet kommer att publiceras i tidskriften "Toxicology In Vitro" i början av år1998.

Programboken med abstracts och deltagarförteckning m.m finns i en mindre upplaga och kan utan kostnad beställas hos CFN:s kansli.

Program

Signal transduction

 Tom Curran, St. Jude Children´s Research Hospital, Memphis, USA
"c-fos and signal transduction in vivo"

Susan Jaken, W. Alton Jones Cell Science Center, Inc, Lake Placid, USA
"Subcellular Targeting of Protein Kinase C Isoenzymes in Normal and Transformed Cells"

Lena Claesson Welsh
"Tyrosine kinase signal transduction"

Thue W. Schwartz, Rigshospitalet, Copenhagen, Denmark
"7TM G-protein coupled receptors - the largest superfamily of drug targets"

Monica Thelestam, Karolinska Institute, Stockholm, Sweden
"Effects of bacterial toxins on small GTP-binding proteins"

Jan-Åke Gustafsson, Karolinska Institute, Huddinge, Sweden
"Impact of environmental pollutants on nuclear receptors"

Keynote lecture
Peter Krammer, German Research Cancer Institute, Heidelberg, Germany
"The cd95(apo-1/fas) apoptosis signal"

Cell cycle/death

Anders Zetterberg, Karolinska Hospital, Stockholm, Sweden
"Cell cycle control and cancer"

Klas Wiman, Karolinska Institute, Stockholm, Sweden
"Regulation of p53-induced cell cycle arrest and apoptosis"

Sten Orrenius, Karolinska Institute, Stockholm, Sweden
"Ca2+ signalling and protease activation in apoptosis"

 Pier-Luigi Nicotera, University of Konstanz, Konstanz, Germany
"Signalling alterations and apoptosis in neurodegeneration"

 Adriano Aguzzi, Zürich, Switzerland
"Prions: neurotoxicity and neuroinvasion"

 Stress response

 James Stevens, W. Alton Jones Cell Science Center, Inc, Lake Placid, USA
"Activating Stress Response Genes: A balancing act between survival and death"

 Richard I. Morimoto, Northwestern University, Evanston, USA
"Sensing stress and protein damage by heat shock factors and molecular chaperones"

 Rune Toftgård, Karolinska Institute, Huddinge, Sweden
"UV-induced activation of the Rel/NF-kB signalling pathway in keratinocytes"

Arne Holmgren, Karolinska Institute, Stockholm, Sweden
"The mammalian thioredoxin system in stress responses and redox regulation"

Tadeusz Wieloch, University Hospital, Lund, Sweden
"Gene expression and signalling in the postischemic brain"

 Application of molecular biology in in vitro toxicology

 Ulf Andersson, Stockholm University, Sweden
"Cytokines"

 Oliver Flint, Bristol-Myers Squibb Pharmaceutical Research Institute, Syracuse, USA
"Relationships between the expression of toxicity in vivo and the effects of xenobiotics on molecular targets in the cell"

 Spencer Farr, Pace-1, Inc, Santa Fe, USA
"Application of gene expression and other molecular endpoints to mechanistic toxicology"

Donald Fox, University of Houston, Houston, USA
"Lead-induced alterations in retinal gene expression and calcium signalling underlie the rod selective apoptosis"

Lorenz Poellinger, Karolinska Institute, Stockholm, Sweden
"Mechanism of signal transduction by the dioxin receptor"